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From reishi to cordyceps to maitake to shiitake, this list of research resources is a great place to go to springboard into the medicinal space.
This Boston Globe article features Dave Demarest and VTea, Reishi mushroom cultivation.
I've spoken with Dave and, though I have yet to visit his operation, I have friends who are familiar with it and send him kudos - Keep up the good work, Dave!
Dave does his cultivation outside, projecting mycelia from his lab into the woods. It would be interesting to see whether some degree of insulation (straw? woodchips? bivuacs?) might enable year-round cultivation, as opposed to the seasonal method currently employed. Just a thought...